Anoikis resistant mediated by FASN promoted growth and metastasis of osteosarcoma

CXCR4-mediated osteosarcoma growth and pulmonary metastasis is promoted by mesenchymal stem cells through VEGF.

Chemokines and chemokine receptor 4 (CXCR4) play an important role in metastasis. CXCR4 is also expressed in the human osteosarcoma cell line 9607-F5M2 (F5M2), which has a high tumorigenic ability and potential for spontaneous pulmonary metastasis. Mesenchymal stem cells (MSCs) contribute to the formation of the tumor stroma and promote metastasis. However, mechanisms underlying the promotion o...

Down-regulation of miR-3928 promoted osteosarcoma growth.

BACKGROUND Osteosarcoma is the most common primary bone malignancy in children and young adults. Most failures of osteosarcoma treatment were due to resistance to chemotherapy. Development of new therapy required elucidation underlying molecular mechanism. Many miRNAs have been proved to be involved in the pathogenesis of osteosarcoma. METHODS MiR-3928 expression level was assayed by qRT-PCR....

Inhibition of Tumor Growth and Lung Metastasis of Osteosarcoma in Vivo by Hyaluronan Oligosaccharides

Introduction Hyaluronan (HA) is a large, linear, negatively charged polysaccharide with molecular weights ranging 10-10, interacting with pericellular matrix, and regulating tumor cell biology, such as proliferation, motility, and invasiveness. Manipulation of HA synthesis alters the hyaluronan rich-matrix and malignant properties (1). Numerous studies suggest that HA interacts with specific ce...

CD151-mediated adhesion is crucial to osteosarcoma pulmonary metastasis

CD151, a tetraspanin family protein involved in cell-cell and cell-extracellular matrix interaction, is differentially expressed in osteosarcoma cell membranes. Thus, this study aimed to investigate the role of CD151 in osteosarcoma metastasis. We analyzed CD151 expression in patient tissue samples using immunohistochemistry. CD151 expression was also silenced with shRNA in osteosarcoma cells o...

Exosome-mediated Lung Metastasis Formation In Osteosarcoma Progression